REVIEW ARTICLE
Local drug delivery for inner ear therapy
ENRIQUE R. PEREZ
∗ , DANA R. LIBMAN ∗ , THOMAS R. VAN DE WATER
Cochlear Implant Research Program, University of Miami Ear Institute & Audiology, Department of Otolaryngology,
University of Miami Miller School of Medicine, Miami, FL 33136 - 1015 USA
Abstract
This review of local drug delivery for inner ear therapy covers the topics of: noise-induced hearing loss (NIHL); vibrationinduced
hearing loss (VHL); cisplatin ototoxicity; aminoglycoside ototoxicity; and mechanical trauma-induced hearing
loss that can occur during the process of cochlear implantation. The cellular, biochemical and molecular mechanisms
involved in the causation of the hearing losses that result from exposure to these diverse traumas to the cochlea and its
auditory sensory epithelium are explored as well as the effi cacy of different drug therapies in their ability to either prevent
or lessen the damage to the cochlear sensory epithelium and ameliorate the level of hearing loss. This review
concludes with a section that explores future strategies for unique methods of drug delivery to the cochlea (e.g. biorelease
from hydrogels via the round window membrane) and the development of novel inner ear therapies (e.g. short interfering
ribonucleic acids, siRNAs) to conserve hearing against trauma associated losses and/or to restore hearing (e.g. stem
cell therapy) following trauma-initiated losses of hair cells and hearing.
2012; 10: 1–20
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